Core F-Technology

Core F-Technology

Fluorine itself is very rare in everyday life, but hundreds of fluorine-containing compounds occur as minerals, medicines, pesticides, and materials. Naturally occurring organo fluorine compounds are extremely rare. Organic fluorine compounds have had a profound impact on the development of bioactive small molecules for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals prescribed or administered in the clinic contain a fluorine atom and 30% of the leading 30 blockbuster drugs by sales contain a fluorine, such as Lipitor and Prozac. All fluorinated pharmaceuticals were mainly based on the introduction of C-F bonds into organic molecules. However, introduction of an N-F bond has never been reported for drug discovery. In particular, Fluoroamine is a chemical compound with formula NH2F is seldom studied. We are the first to make use of Fluoroamine now for custom new drug discovery research.

 

Fluoroamine will be a very useful starting material for making N-F containing drug like molecules. We have also made N-fluoroamino acids and N-fluoroaminonucleosides available for the first time. If you are interested in any custom chemistry services using Fluoroamine, please write to us.

 

                              Synthesis of N-Fluoroadenosine By Fluoroamine

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